You can make polycyclic, heterocyclic, and aromatic rings. Nolan, M. It remains important to consider the substitution pattern of the alkene and the activity and functional-group compatibility of the catalyst.
Heterocycles containing a carbon-carbon double bond can also be prepared via RCM.
Without the Lewis acidonly the membered dimer ring was observed. Ma, C. An isomerization-ring-closing metathesis strategy for the synthesis of substituted benzofurans W. The selectivity is attributed to the increased steric clash between the catalyst ligands and the metallacyclobutane intermediate that is formed.
Borys, D. Cross-coupling reactions of alkenyl halides or alkenyl nucleophiles, which establish carbon-carbon single bonds adjacent to C-C double bonds, have also emerged as complimentary alternatives to olefination reactions.